Rose Leslie is starring in a powerful music video exploring multiple sclerosis for the pianist and composer Fabio D'Andrea.
The actress, 36, depicts the daily struggles of somebody living with the condition affecting the brain and nerves in the emotionally-charged short film.
Ahead of Hope Reborn's Friday release, MailOnline can exclusively tease a clip in which the Game Of Thrones star winces and wails in pain as she struggles to stand after waking up.
Rose said of the project: 'I have been a passionate supporter of the MS Society for a few years now, so when they approached me to take part in this music video, I thought it would be a wonderful opportunity to raise awareness for multiple sclerosis and to highlight the invisible symptoms that people who are living with MS will often experience.
'I hope that it will also provide a positive message to anyone who does have this condition - that it's still possible to live a full life.
Talented: Rose Leslie is starring in a powerful music video exploring multiple sclerosis for the pianist and composer Fabio D'Andrea
'I hope that this music video will help to raise vital funds for the MS Society and Overcoming MS as well as increasing understanding of the condition.'
Fabio notably worked with Mel B for his 2021 music video, Love Should Not Hurt, in which the Spice Girl highlighted the effects of domestic violence, with proceeds going to Women's Aid.
Other music videos in his catalogue include Something Left To Love, starring Russell Tovey, which portrays the isolation and trauma of mental health.
Natalie Dormer, Emma Rigby, Douglas Booth & Ellie Bamber have also filmed for the artist's projects.
He has now created the first ever piano-video album, 24, which consists of 24 original piano pieces (one in every key), each accompanied by a music video starring a Hollywood actor and directed by Fabio himself.
As a supporter of the charity Overcoming MS, Fabio wanted to show that MS can be both invisible but also very visible at times and increasingly so, as the condition progresses.
He has sought to portray this juxtaposition on camera and in his composition.
The single, which will be available to purchase from iTunes & Amazon on Friday, will raise money for charities Overcoming MS and the MS Society.
Powerful: The actress, 36, depicts the daily struggles of somebody living with the condition affecting the brain and nerves in the emotionally-charged short film
Emotive: Ahead of Hope Reborn's Friday release, MailOnline can exclusively tease a clip in which the Game Of Thrones star winces and wails in pain as she struggles to stand
An award-winning film director in addition to acclaimed musician, Fabio directed these visually stunning and surprising technical works which shed new light on causes close to his heart.
It is unusual to have an artist support a number of different causes and when asked why he has chosen to do this, Fabio said: 'Many of the famous composers in the past were able to address social issues of their time through their operas and ballets.
'Music videos are the modern equivalent creative medium that let me address issues on a broad scale.'
For Fabio, both the musical integrity and the opportunity to address issues that affect society through his music videos drives his unique vision for this album.
Skilled: Fabio said: 'Being able to use music without lyrics, and acting without a script, I have found a way to speak'
He said: 'Being able to use music without lyrics, and acting without a script, I have found a way to speak.
'What makes me so unusual as an artist is that my voice can be heard without me having to say a single word. My music and visuals do all the talking.'
The unprecedented album connects various art forms, and is part of Fabio's visionary long-term goal of establishing a label to support other forward-thinking artists whose creative output stretches beyond the confines of the current music-industry model.
Set to an emotive soundtrack of Fabio's cascading piano music, the video combines the three art forms – film, contemporary piano music and dance – to pack an even more effective punch.
WHAT IS MULTIPLE SCLEROSIS?
Multiple sclerosis (known as MS) is a condition in which the immune system attacks the body and causes nerve damage to the brain and spinal cord.
It is an incurable, lifelong condition. Symptoms can be mild in some, and in others more extreme causing severe disability.
MS affects 2.3 million people worldwide - including around one million in the US, and 100,000 in the UK.
It is more than twice as common in women as it is in men. A person is usually diagnosed in their 20s and 30s.
The condition is more commonly diagnosed in people of European ancestry.
The cause isn't clear. There may be genes associated with it, but it is not directly hereditary. Smoking and low vitamin D levels are also linked to MS.
Symptoms include fatigue, difficulty walking, vision problems, bladder problems, numbness or tingling, muscle stiffness and spasms, problems with balance and co-ordination, and problems with thinking, learning and planning.
The majority of sufferers will have episodes of symptoms which go away and come back, while some have ones which get gradually worse over time.
Symptoms can be managed with medication and therapy.
The condition shortens the average life expectancy by around five to 10 years.
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